Support For Men With Advanced Prostate Cancer

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Frequently asked questions about PROVENGE treatment


What side effects can occur with PROVENGE?

PROVENGE is generally well tolerated and most infusion side effects resolve in a couple of days.

There are potential risks associated with PROVENGE:

  • In controlled clinical trials, 71.2% of patients in the PROVENGE group developed an acute infusion reaction
  • The most common events (≥ 20%) were chills, fever, and fatigue. In 95.1% of patients reporting acute infusion reactions, the reactions were mild or moderate. Fevers and chills generally resolved within 2 days (71.9% and 89%, respectively)
  • 1.5% of men discontinued their treatment with PROVENGE due to side effects

The most common side effects of PROVENGE prostate cancer treatment include:

  • Chills
  • Back pain
  • Joint ache
  • Fatigue
  • Nausea
  • Headache
  • Fever

PROVENGE infusion can cause serious reactions. Tell your doctor right away if:

  • You have breathing problems, chest pains, racing heart or irregular heartbeats, high or low blood pressure, dizziness, fainting, nausea, or vomiting after getting PROVENGE. Any of these may be signs of heart or lung problems.
  • You develop numbness or weakness on one side of the body, decreased vision in one eye, or difficulty speaking. Any of these may be signs of a stroke.
  • You develop symptoms of thrombosis which may include: pain and/or swelling of an arm or leg with warmth over the affected area, discoloration of an arm or leg, unexplained shortness of breath, chest pain that worsens on deep breathing.
  • You get a fever over 100°F, or redness or pain at the infusion or collection sites. Any of these may be signs of infection.

These are not all the possible side effects of PROVENGE treatment. For more information, talk with your doctor. Please see Important Safety Information.


Learn more about when and why PROVENGE might be the right treatment for you.

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