Is PROVENGE Right For Me?

PROVENGE is a treatment option for certain men with
metastatic castrate resistant prostate cancer.

You may be able to receive PROVENGE therapy if:

  • You are on hormone therapy and have rising PSA levels
  • Your cancer has spread from the prostate to other places, such as your bones
  • You are not taking narcotics for cancer-related pain

Ask your doctor if PROVENGE is right for you.

When is the right time for PROVENGE?

Since PROVENGE is an immunotherapy that boosts your immune system, it should be used early on in your advanced prostate cancer treatment plan.

In fact, the National Comprehensive Cancer Network (NCCN) guidelines recommend using PROVENGE first, and it is the only immunotherapy treatment option for men with advanced prostate cancer with few or no cancer-related symptoms. PROVENGE boosts your immune system to help it fight your advanced prostate cancer.

After your PROVENGE treatment, other options such as radiotherapy, hormone therapy, and chemotherapy may still be available to you.

Example of a Possible Prostate Cancer Treatment Path

Treating Advanced Prostate Cancer

Doctor Discussion Guide

Find tips on talking to your doctor about whether PROVENGE could be right for you.
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Find a PROVENGE Treatment Center


PROVENGE® (sipuleucel-T) is a prescription medicine that is used to treat certain patients with advanced prostate cancer. PROVENGE is made from your own immune cells.


  • Before getting PROVENGE, tell your doctor about all your medical problems, including problems with your heart or lungs, or if you have had a stroke
  • Tell your doctor about all the medicines you take, including prescription and nonprescription drugs, vitamins, and dietary supplements
  • PROVENGE is made from your own immune cells, collected approximately 3 days before each scheduled infusion of PROVENGE. The collection is called “leukapheresis” (pronounced loo-kuh-fuh-REE-sis). You will get PROVENGE in 3 intravenous infusions (put into your veins), about 2 weeks apart. Each infusion takes about 60 minutes. You will then be monitored for at least 30 minutes. Your doctor will give you a schedule for your cell collection and infusion appointments. It is very important that you arrive on time for your appointments
  • The most common side effects of PROVENGE include chills, fatigue, fever, back pain, nausea, joint ache, and headache. These are not all the possible side effects of PROVENGE treatment
  • PROVENGE infusion can cause serious reactions. Tell your doctor right away if you:
    • Have breathing problems, chest pains, racing heart or irregular heartbeats, high or low blood pressure, dizziness, fainting, nausea, or vomiting after getting PROVENGE. Any of these may be signs of heart or lung problems
    • Develop numbness or weakness on one side of the body, decreased vision in one eye, or difficulty speaking. Any of these may be signs of a stroke
    • Develop symptoms of thrombosis which may include: pain and/or swelling of an arm or leg with warmth over the affected area, discoloration of an arm or leg, unexplained shortness of breath, chest pain that worsens on deep breathing
    • Get a fever over 100°F, or redness or pain at the infusion or collections sites. Any of these may be signs of infection
  • Tell your doctor about any side effect that concerns you or does not go away. For more information, talk with your doctor

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

Click here for full Prescribing Information.