Talk to Your Doctor About PROVENGE

If you are interested in PROVENGE, it is important to talk to your doctor to find out if the time is right to start your treatment.

Some doctors may not have the facilities needed to administer PROVENGE. If your doctor isn’t equipped to provide PROVENGE, talk to your doctor about a referral.

To locate a doctor that can administer PROVENGE, simply enter your ZIP code in our Doctor Locator.

While talking to your doctor, It is important to remember that PROVENGE may not affect your PSA levels. In the PROVENGE clinical trials, the main goal was not to lower PSA levels—it was to extend life. So even if your PSA levels do not go down, PROVENGE may help you live longer.

Talk to your doctor about bone scans

Bone scans provide your doctor with important information regarding the spread of prostate cancer and how the disease is progressing.

When prostate cancer spreads, or becomes metastatic, it usually moves into the bones, the most common area being the spine. This is why bone scans are an important step to take when determining whether or not the time may be right for PROVENGE.

It is important to talk to your doctor about getting a bone scan to help determine if your cancer has spread. Along with increasing PSA levels, a bone scan can help to give your doctor a better idea of whether or not immunotherapy is an option.

Questions to ask your doctor about PROVENGE

Below are some examples of questions that may help you at your next doctor’s appointment.

  • What are the possible advantages of taking PROVENGE?
  • What are the possible side effects of PROVENGE?
  • How is PROVENGE administered and how long does it take?
  • Do I need to get bone scans or other tests before my course of treatment with PROVENGE?
  • Does your office administer PROVENGE?
    • If not, do you recommend a doctor that does? How can I get started with PROVENGE?


Financial Support May Be Available

More than 90% of Medicare fee-for-service (FFS) patients receiving PROVENGE are expected to have minimal to no out-of-pocket costs.
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Find a PROVENGE Treatment Center


PROVENGE® (sipuleucel-T) is a prescription medicine that is used to treat certain patients with advanced prostate cancer. PROVENGE is made from your own immune cells.


  • Before getting PROVENGE, tell your doctor about all your medical problems, including problems with your heart or lungs, or if you have had a stroke
  • Tell your doctor about all the medicines you take, including prescription and nonprescription drugs, vitamins, and dietary supplements
  • PROVENGE is made from your own immune cells, collected approximately 3 days before each scheduled infusion of PROVENGE. The collection is called “leukapheresis” (pronounced loo-kuh-fuh-REE-sis). You will get PROVENGE in 3 intravenous infusions (put into your veins), about 2 weeks apart. Each infusion takes about 60 minutes. You will then be monitored for at least 30 minutes. Your doctor will give you a schedule for your cell collection and infusion appointments. It is very important that you arrive on time for your appointments
  • The most common side effects of PROVENGE include chills, fatigue, fever, back pain, nausea, joint ache, and headache. These are not all the possible side effects of PROVENGE treatment
  • PROVENGE infusion can cause serious reactions. Tell your doctor right away if you:
    • Have breathing problems, chest pains, racing heart or irregular heartbeats, high or low blood pressure, dizziness, fainting, nausea, or vomiting after getting PROVENGE. Any of these may be signs of heart or lung problems
    • Develop numbness or weakness on one side of the body, decreased vision in one eye, or difficulty speaking. Any of these may be signs of a stroke
    • Develop symptoms of thrombosis which may include: pain and/or swelling of an arm or leg with warmth over the affected area, discoloration of an arm or leg, unexplained shortness of breath, chest pain that worsens on deep breathing
    • Get a fever over 100°F, or redness or pain at the infusion or collections sites. Any of these may be signs of infection
  • Tell your doctor about any side effect that concerns you or does not go away. For more information, talk with your doctor

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

Click here for full Prescribing Information.