Starting PROVENGE—Preparing for Treatment

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Once your PROVENGE treatment schedule is set, you will receive a complimentary Patient Comfort Kit, which includes items designed to help you relax during treatment sessions.

Before your cell collection procedure, you should:

  • bullet imageMake sure to drink more water than usual 2 to 3 days before your treatment to stay well hydrated
  • bullet imageAvoid drinking caffeinated beverages on the day of each cell collection procedure
  • bullet imageEat a calcium-rich breakfast, which may include yogurt, milk, calcium-fortified orange juice or cereal, bananas, blueberries, or almonds
  • bullet imageWear comfortable, loose-fitting clothing, especially clothing with sleeves that can be raised above the elbow
  • bullet imageHave a driver lined up for the ride home since most people feel fatigued after the cell collection procedure

Remember, PROVENGE may not affect your PSA levels

PROVENGE is specifically designed to attack your advanced prostate cancer cells. Although your PSA levels may not decrease, PROVENGE may still help you live longer.

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Caregiver Resources

Check out online support resources and Web sites geared specifically toward caregivers.
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Advocacy and Additional Resources

Find professional societies and other organizations that can help during your prostate cancer journey.
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Financial Support Is Available

75% of patients receiving PROVENGE are expected to have minimal to $0 out-of-pocket costs.
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Get Your Free PROVENGE Jumpstart Kit


Find a PROVENGE Treatment Center


PROVENGE® (sipuleucel-T) is approved by the FDA as an autologous cellular immunotherapy for the treatment of asymptomatic or minimally symptomatic metastatic castrate resistant (hormone refractory) prostate cancer.


PROVENGE is made from your own immune cells. Your cells will be collected at a cell collection center approximately 3 days before each scheduled infusion of PROVENGE. There can be risks associated with the cell collection process, which you should discuss with your doctor before deciding to begin treatment with PROVENGE.

PROVENGE can cause serious reactions. In controlled clinical trials for the treatment of prostate cancer, serious reactions reported in patients in the PROVENGE group included reactions resulting from the infusion of the drug, which occurred within 1 day of infusion, and strokes. Severe infusion reactions included chills, fever, fatigue, weakness, breathing problems (shortness of breath, decreased oxygen level, and wheezing), dizziness, headache, high blood pressure, muscle ache, nausea, and vomiting. Tell your doctor right away if you have breathing problems, chest pains, racing heart or irregular heartbeats, dizziness, nausea, or vomiting after getting PROVENGE because any of these may be signs of heart or lung problems.

The most common side effects reported with PROVENGE were chills, fatigue, fever, back pain, nausea, joint ache, and headache. These are not all the possible side effects of PROVENGE treatment. For more information, talk with your doctor.

Tell your doctor about all your medical problems including heart problems, lung problems or a history of stroke.

Tell your doctor right away if you get a fever over 100°F, or redness at the cell collection or infusion sites, because any of these may be signs of infection.

Tell your doctor about all the medicines you take, including prescription and nonprescription drugs, vitamins, and dietary supplements.

Tell your doctor about any side effect that concerns you or does not go away.

For more information on PROVENGE, please see the Full Prescribing Information or call 1-800-667-5924.

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