PROVENGE Treatment Process

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Each dose of PROVENGE is personalized by taking your own blood cells and reprogramming them to jumpstart your immune system. This section also talks about the importance of PSA levels and the role they play in the PROVENGE treatment process. Here’s a step-by-step overview of the process:


Step 1: Cell collection

To make each dose, blood will be drawn from your body and passed through a machine that collects a small portion of your immune cells, along with some platelets and a small number of red blood cells. The machine returns the rest of the cells and blood to your body.


Step 2: PROVENGE treatment

Your immune cells are then sent to an FDA-approved manufacturing facility to be made into a dose of PROVENGE specifically for you.

  • Each dose of PROVENGE is given about 3 days after your cell collection procedure, and your appointment will take about 2 hours
  • The PROVENGE infusion procedure will take place at a different location than your cell collection procedure, usually your physician’s office

PROVENGE Treatment Cycle for Advanced Prostate Cancer

After 6 appointments, your treatment with PROVENGE is complete.

As this sample schedule shows, your time commitment for PROVENGE is only 6 appointments over about a month. After these appointments, no future treatments with PROVENGE are necessary.

Example Commitment Calendar of PROVENGE Treatment Schedule


The importance of keeping scheduled appointments

It’s important to keep all of your scheduled treatment appointments and arrive prepared. Your dose of PROVENGE is custom made for you and has a short shelf life. If you miss an infusion appointment, your personal dose of PROVENGE will expire and can no longer be used. As a result, you’d have to repeat the cell collection procedure so a new custom dose of PROVENGE could be manufactured.

We encourage you to use the calendar inside your Patient Comfort Kit to set reminders for yourself. You can also ask family members or friends to mark your procedure dates on their calendars too, to help ensure that you do not miss any appointments.


Important information about PROVENGE and PSA levels

The prostate-specific antigen (PSA) test is often used to monitor progression of prostate cancer and how effectively your treatment is controlling the disease. However in the PROVENGE clinical trial, the main goal was not to lower PSA levels—it was to extend life. So even if your PSA levels do not go down, PROVENGE may help you live longer.

Therefore you shouldn’t worry if your PSA levels don’t change, since changes in PSA levels are not indicative of how well your PROVENGE treatment is working. Be sure to talk to your doctor if you have any questions or concerns about your PSA levels.

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Preparing for Treatment

Following Treatment Instructions

Rollin was careful to follow his treatment instructions.
See Rollin’s story ›

Knowing What To Expect From the Treatment Experience

Don found that the PROVENGE treatment process was straightforward.
See Don’s story ›

Financial Support Is Available

75% of patients receiving PROVENGE are expected to have minimal to $0 out-of-pocket costs.
Learn more ›

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INDICATION

PROVENGE® (sipuleucel-T) is an autologous cellular immunotherapy indicated for the treatment of asymptomatic or minimally symptomatic metastatic castrate-resistant (hormone-refractory) prostate cancer.

IMPORTANT SAFETY INFORMATION

Before getting PROVENGE, tell your doctor if you:

  • Have heart problems
  • Have lung problems
  • Have a history of stroke
  • Take any other medicines including prescription and nonprescription drugs, vitamins, and dietary supplements.

What are the possible side effects of PROVENGE

PROVENGE infusion can cause serious reactions.

Tell your doctor right away if you:

  • Have breathing problems, chest pains, racing heart or irregular heartbeats, high or low blood pressure, dizziness, fainting, nausea, or vomiting after getting PROVENGE. Any of these may be signs of heart or lung problems.
  • Develop numbness or weakness on one side of the body, decreased vision in one eye or difficulty speaking. Any of these may be signs of a stroke.
  • Develop symptoms of thrombosis which may include pain and/or swelling of an arm or leg with warmth over the affected area, discoloration of an arm or leg, unexplained shortness of breath or chest pain that worsens on deep breathing.
  • Get a fever over 100°F, or redness or pain at the infusion or collection sites. Any of these may be signs of infection.

The most common side effects of PROVENGE include chills, fatigue, fever, back pain, nausea, joint ache, and headache.

These are not all the possible side effects of PROVENGE treatment. For more information, talk with your doctor.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

For more information on PROVENGE, please see the Full Prescribing Information or call 1-800-667-5924.

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