What Is PROVENGE Immunotherapy?

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PROVENGE is the first and only FDA-approved immunotherapy for advanced prostate cancer

PROVENGE is the only personalized treatment that is clinically proven to help extend life in certain men with advanced prostate cancer.

PROVENGE is an immunotherapy that takes your own immune cells and reprograms them to attack your advanced prostate cancer. This process delivers a treatment designed just for you.

PROVENGE has proven results as an advanced prostate cancer immunotherapy

In the clinical trial (IMPACT) that supported FDA approval, more men treated with PROVENGE lived longer than men not treated with PROVENGE.

  • More men in the PROVENGE group were alive 3 years after the start of the study than men not treated with PROVENGE
  • PROVENGE reduced the risk of death by 22.5% for patients in the PROVENGE group
  • Only 1.5% of men discontinued treatment with PROVENGE due to side effects

PROVENGE—Prostate Cancer Survival Rate

Percentage of Patients in the PROVENGE Group Alive After 1, 2, and 3 Years

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How Does PROVENGE Work?


PROVENGE is a treatment option for certain men with metastatic castrate resistant prostate cancer.
Find out if PROVENGE could be right for you ›

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PROVENGE® (sipuleucel-T) is an autologous cellular immunotherapy indicated for the treatment of asymptomatic or minimally symptomatic metastatic castrate-resistant (hormone-refractory) prostate cancer.


Before getting PROVENGE, tell your doctor if you:

  • Have heart problems
  • Have lung problems
  • Have a history of stroke
  • Take any other medicines including prescription and nonprescription drugs, vitamins, and dietary supplements.

What are the possible side effects of PROVENGE

PROVENGE infusion can cause serious reactions.

Tell your doctor right away if you:

  • Have breathing problems, chest pains, racing heart or irregular heartbeats, high or low blood pressure, dizziness, fainting, nausea, or vomiting after getting PROVENGE. Any of these may be signs of heart or lung problems.
  • Develop numbness or weakness on one side of the body, decreased vision in one eye or difficulty speaking. Any of these may be signs of a stroke.
  • Develop symptoms of thrombosis which may include pain and/or swelling of an arm or leg with warmth over the affected area, discoloration of an arm or leg, unexplained shortness of breath or chest pain that worsens on deep breathing.
  • Get a fever over 100°F, or redness or pain at the infusion or collection sites. Any of these may be signs of infection.

The most common side effects of PROVENGE include chills, fatigue, fever, back pain, nausea, joint ache, and headache.

These are not all the possible side effects of PROVENGE treatment. For more information, talk with your doctor.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

For more information on PROVENGE, please see the Full Prescribing Information or call 1-877-336-3736.

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