What Is PROVENGE Immunotherapy?

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PROVENGE is the first and only FDA-approved immunotherapy for advanced prostate cancer

PROVENGE is the only personalized treatment that is clinically proven to help extend life in certain men with advanced prostate cancer.

PROVENGE is an immunotherapy that takes your own immune cells and reprograms them to attack your advanced prostate cancer. This process delivers a treatment designed just for you.

The following video contains important questions that you can ask your doctor while considering PROVENGE.


PROVENGE has proven results as an advanced prostate cancer immunotherapy

In the clinical trial (IMPACT) that supported FDA approval, more men treated with PROVENGE lived longer than men not treated with PROVENGE.

  • More men in the PROVENGE group were alive 3 years after the start of the study than men not treated with PROVENGE
  • PROVENGE reduced the risk of death by 22.5% for patients in the PROVENGE group
  • Only 1.5% of men discontinued treatment with PROVENGE due to side effects

PROVENGE—Prostate Cancer Survival Rate

Percentage of Patients in the PROVENGE Group Alive After 1, 2, and 3 Years

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How Does PROVENGE Work?


PROVENGE is a treatment option for certain men with metastatic castrate resistant prostate cancer.
Find out if PROVENGE could be right for you ›

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PROVENGE® (sipuleucel-T) is approved by the FDA as an autologous cellular immunotherapy for the treatment of asymptomatic or minimally symptomatic metastatic castrate resistant (hormone refractory) prostate cancer.


PROVENGE is made from your own immune cells. Your cells will be collected at a cell collection center approximately 3 days before each scheduled infusion of PROVENGE. There can be risks associated with the cell collection process, which you should discuss with your doctor before deciding to begin treatment with PROVENGE.

PROVENGE can cause serious reactions. In controlled clinical trials for the treatment of prostate cancer, serious reactions reported in patients in the PROVENGE group included reactions resulting from the infusion of the drug, which occurred within 1 day of infusion, and strokes. Severe infusion reactions included chills, fever, fatigue, weakness, breathing problems (shortness of breath, decreased oxygen level, and wheezing), dizziness, headache, high blood pressure, muscle ache, nausea, and vomiting. Tell your doctor right away if you have breathing problems, chest pains, racing heart or irregular heartbeats, dizziness, nausea, or vomiting after getting PROVENGE because any of these may be signs of heart or lung problems.

The most common side effects reported with PROVENGE were chills, fatigue, fever, back pain, nausea, joint ache, and headache. These are not all the possible side effects of PROVENGE treatment. For more information, talk with your doctor.

Tell your doctor about all your medical problems including heart problems, lung problems or a history of stroke.

Tell your doctor right away if you get a fever over 100°F, or redness at the cell collection or infusion sites, because any of these may be signs of infection.

Tell your doctor about all the medicines you take, including prescription and nonprescription drugs, vitamins, and dietary supplements.

Tell your doctor about any side effect that concerns you or does not go away.

For more information on PROVENGE, please see the Full Prescribing Information or call 1-800-667-5924.

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